Endocrine Abstracts

In clinical practice, dyslipidaemia defines the elevated plasma total cholesterol, LDL cholesterol or triglycerides or the decreased HDL cholesterol levels. In recent years however, new laboratory methods helped us understand that the functions of lipoproteins are more important than their amounts. Dyslipidaemia is one of the most important and correctable risk factors for the atherosclerotic cardiovascular diseases (CVD). The epidemiological data recurrently show a very signi...

Primary hyperparathyroidism (PHPT) is the third common disorder of the endocrine system. It reaches a peak incidence between ages 50–60. Biochemical screening has increased its incidence up to one per 1000 (USA), and most cases are presented with asymptomatic mild hypercalcemia. The most common cause in affected individuals is a functioning single parathyroid adenoma. In advanced cases, bones (brown tumours, osteitis fibrosa cystica) and the kidney (nephrolithiasis, nephr...

Background: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly described indolent thyroid tumor with well-defined histopathological diagnostic criteria. Even though the histopathologic features and diagnostic criteria for NIFTP are well-established, preoperative diagnosis using sonographic or fine needle aspiration findings has yet to be confirmed. The aim of this study is to compare the clinical, sonographic, and cytological charac...

Introduction: No consensus guideline on the treatment of hypoparathyroidism. Hypoparathyroidism is a disease characterized by hypocalcaemia and insufficient PTH. Conventional therapy includes calcium and active vitamin D supplementation, often in large doses.Case report: A 31-year-old woman presented with hypercalcemia. Serum calcium and phosphorus levels were 10.5 and 2.56 mg/dl respectively. The serum PTH level was increased (1619 pg/ml). The serum 25-...

Objective: To compare the impact of 4 surgical procedures (mini gastric bypass [MGB], sleeve gastrectomy [SG], ileal transposition [IT], and transit bipartition [TB]) versus medical management on gut peptide secretion, beta cell function, and resolution of hyperglycaemia in type 2 diabetes (T2DM).Research design and methodsA mixed-meal tolerance test (MMTT) was administered 6–24 months after each surgical procedure (mini gast...

Background and Aim: Prevalence of Hashimoto’s thyroiditis is increasing in Turkey. GH deficiency has been reported to associate with this disorder in several different ethnic population. The aim of this study was to evaluate GH deficiency in the population with Hashimoto’s thyroiditis.Materials and methods: Euthyroid Hashimoto’s thyroiditis patients, who admitted to the Department of Endocrinology and Metabolism of Hacettepe University, we...

Background: Maternally inherited diabetes and deafness (MIDD) is a rare form of diabetes due to defects in mitochondrial DNA (mtDNA). Maternal transmission of diabetes and neurosensorial deafness are the main clinical features of MIDD followed by other mitochondrial disorders, myopathies, and macular dystrophy. 3243 A>G is the mutation most frequently associated with this condition, but also other mtDNA variants have been linked with MIDD. We describe the case presenting w...

Introduction: Primary empty sella (PES) is often found incidentally during neuroradiological studies. Although pituitary function is usually normal in patients with PES, it could be associated with serious clinical conditions including different degrees of hypopituitarism. Post-operative empty sella (POES), the most common group, results from pituitary adenoma and their treatments. Our aim is to compare anterior pituitary functions and quality of life (QoL) with Short Form-36 ...

Background and Aim: Prolactinoma is the most common type of functional pituitary tumor in adults. Giant prolactinomas are defined as tumors achieve a diameter >4 cm and often have very high serum prolactin level. In our previous study showed that endoscopic endonasal pituitary surgery is a very convenient procedure for the patient due to low morbidity and high efficiency. In this study we evaluated endoscopic endonasal pituitary surgery series in patients with prolactinoma...

Background: Several studies showed that there is a relationship between vitamin and mineral status and muscle strength. In particular this is the case for handgrip strength (HS) and vitamin D deficiency. In bariatric surgery there is a risk of decrease in muscle strength after surgery and also vitamin and mineral deficiencies are not uncommon. The aim of this study is to assess the effect of low vitamin 25 (OH) cholecalciferol levels, high dose cholecalciferol supplementation ...